Human Umbilical Cord Mesenchymal Stem Cells in Combination with Hyaluronic Acid Ameliorate the Progression of Knee Osteoarthritis

The aim of this study is to evaluate the feasibility and usefulness human umbilical cord mesenchymal stem cells (hUC-MSCs) hyaluronan acid (HA) combination attenuate osteoarthritis progression in knee while simultaneously providing some insights on mitigation mechanism. In vitro, effect hUC-MSCs with HA treatment chondrocyte cell viability cytokine profile were analyzed. Additionally, antioxidation capability hUC-MSCs-CM (conditioned medium) towards H2O2-induced damage was evaluated. addition increased hUC-MSC secretion, such as Dickkopf-related protein 1 (DKK-1) hepatocyte growth factor (HGF), no adverse observed. vivo, intra-articular injection a mono-iodoacetate (MIA)-induced (KOA) rat model performed investigated. Attenuation KOA MIA-damaged seen best compared vehicle control or each individual element. Combining resulted synergistic effect, increasing therapeutic incurring observable effects. Therefore, combinatorial therapy feasible has promising potential ameliorate progression.